Tamoxifen (TAM), a non-steroidal antiestrogen, used as a chemotherapeutic and chemopreventive agent for breast cancer.
6/1/1999 · In the 1970s three laboratory observations emerged that merited evaluation in clinical trial: 1) tamoxifen blocks estrogen binding to the ER, making patients with ER-positive disease more likely to respond than those with ER-negative disease , 2) tamoxifen prevents mammary cancer in rats (86, 87) so the drug could reduce the incidence of primary breast cancer, and 3) long-term treatment was.
Tamoxifen is an antiestrogen that has been widely used to prevent recurrence of breast cancer after surgical excision in women aged 40 and older and to treat metastatic breast cancer in postmenopausal women with estrogen receptor–positive disease.
A loading dose: 1. Rapidly achieves drug levels in the therapeutic range 2. Requires four- to five-half-lives to attain 3. Is influenced by renal function 4. Is directly related to the drug circulating to the target tissues 7. The point in time on the drug concentration curve that indicates the first sign of a therapeutic effect .
A loading dose: Rapidly achieves drug levels in the therapeutic range 7. The point in time on the drug concentration curve that indicates the first sign of a therapeutic effect is the: Onset of action 8. Phenytoin requires that a trough level be drawn. Peak and trough levels are done: To determine if a drug is in the therapeutic range 9.
